“Known Knowns, Known Unknowns, & Unknown Unknowns”: Computational Science challenges for analysis of multi-dimensional DNA matrices in Evolutionary & Population Genomics

نویسنده

  • Steven M. Carr
چکیده

The advent of so-called NextGen DNA sequencing methods has massively increased the rate at which DNA sequence information can be generated, and the volume and complexity of the data matrices that apply to biological questions, including molecular and organismal evolution and population biology. One such approach is the analysis of complete mitochondrial DNA (mtDNA) genomes from multiple species simultaneously, by means of a “sequencing by hybridization” microarray biotechnology, the “ArkChip”. I review mitogenomic biology and biotechnology, describe some of the known knowns of bioinformatic information content and its computational challenges, outline new computational strategies for known unknowns of evolutionary trees (phylogeny) and population biology structures in time and space (phylogeography), and speculate on future application of Computational Science to biological unknown unknowns.

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تاریخ انتشار 2013